To identify novel biomarkers for the two most common preneoplastic pancreatic lesions, PanIN and IPMN, we resected pancreata from established GEM of PDAC: 13 Ptf1a+/Cre;Kras+/G12D, 8 Ptf1a+/Cre;Kras+/G12D;Ela-Tgfα and 5 Ptf1a+/Cre;Kras+/G12D;Ela-Tgfa;Trp53+/LSL-R172H mice of mixed age (3 to 18 month, depending on the genotype). Here, KRAS is linked to pancreatic intraductal papillary-mucinous neoplasm.