The dose-dependent effects of TS on FOXM1 mRNA and protein expression were examined in LP9 and MM cells, and as reported by others [31], TS inhibited expression of FOXM1 by down-regulating levels of FOXM1 mRNA (not shown) and protein (Fig. 3A, lanes 2–5). The gene discussed is FOXM1; the disease is Miyoshi myopathy.