From the cellular point of view, the A3AR agonist 2-chloro-N6-(3-iodobenzyl)adenosine-5′-N-methyl-uronamide (Cl-IB-MECA) inhibited tumor growth via de-regulation of the NF-kB signal transduction pathways, resulting in apoptosis of tumor cells [10]. This evidence concerns the gene ADORA3 and neoplasm.