In this study we included five SNPs associated with optic disc area (rs1192415 near CDC7/TGFBR3; rs9607469 near CARD10; rs190004, rs7916697 and rs3858145 near ATOH7 ) and three SNPs related with VCDR (rs1063192 in CDKN2B; rs10483727 near SIX1; and rs4977756 near CDKN2B-AS1) to establish their roles in the pathogenesis of POAG in a population of African descent. The gene discussed is TGFBR3; the disease is open-angle glaucoma.