A recent GWAS for POAG using a discovery cohort of 590 POAG cases with severe visual field loss and 3,956 controls also identified the POAG locus at CDKN2B/CDKN2B-AS1, with the most highly associated SNP being rs4977757 (P = 4.70×10−9) [25]. The gene discussed is CDKN2B; the disease is open-angle glaucoma.