SIX1 and open-angle glaucoma: A meta-analysis using data from six independent studies comprising 3,161 glaucoma cases and 42,837 controls found evidence for rs190004 (near ATOH7), rs1063192 (in CDKN2B and the overlapping gene CDKN2B-AS1) and rs10483727 (near SIX1 gene) significantly associated with POAG [24].