While B95-8-LMP1 is relevant to B cell malignancies, we reason that 2117-LMP1 might be more relevant to NPC development, in particular to the high-incidence areas of NPC, based on the finding that the EBV strain encoding 2117-LMP11 was present in the vast majority (86%) of NPC specimens in Hong Kong [16]. This evidence concerns the gene PDLIM7 and nasopharyngeal carcinoma.