We also found that the castration-resistant prostate cancer AR regulated M-phase genes CDC20, CDK1, and UBE2C [27], were decreased in response to MAP3K11 knockdown, although the decrease in transcription of these genes may reflect the inhibition of growth triggered by MAP3K11 knockdown and not represent altered AR transcriptional activity. Here, UBE2C is linked to Familial prostate cancer.