Hs cTn-I remained significantly higher in RA patients after adjustment for age, race, and sex (p = 0.002)(Figure 2- Model 1); age, race, sex and cardiovascular risk factors (p = 0.004)(Figure 2- Model 2); age, race, sex, and markers of inflammation (p = 0.008)(Figure 2- Model 3); and age, race, sex, CV risk factors, markers of inflammation, and NT-proBNP (p = 0.029)(Figure 2- Model 4). This evidence concerns the gene NPPB and rheumatoid arthritis.