For example, PD-LI, the ligand for PD-1 is expressed in up to 50% of invasive ductal carcinomas and is associated with worse prognostic indices.[46] Grosso et al. showed that LAG 3 blockade resulted in increased accumulation and function of antigen-specific CD8 T cells within organs and tumors that express their cognate antigen. The gene discussed is CD8A; the disease is invasive ductal breast carcinoma.