In order to explore the pathophysiological role of macrophage HO-1 in this disease setting, we performed a bone marrow transplantation (BMT) experiment on irradiated B6 mice with bone marrow cells isolated from wild-type (WT) or HO-1+/− mice to assess the role of hematopoietic HO-1 on HFD-induced adipose inflammation and insulin resistance in animals. This evidence concerns the gene HMOX1 and inflammation.