HMOX1 and peritonitis: It has been shown that the extent of macrophage accumulation in the inflammatory site in the late phase is influenced by the emigration of macrophages to lymphatics [42] We speculated that HO-1 haploinsufficiency has similar effect on both migration and emigration of macrophages in the early and late phases of peritonitis, resulting in the accumulation of macrophages in peritoneum of HO-1+/− mice to a similar extent as that in WT mice at 4 days after thioglycollate injection.