The initial discovery of VEGF as a secreted molecule was observed in rodent and human tumor cell lines, and the protein was believed to be a mitogen specific to endothelial cells.[25]–[28] Subsequently, VEGF was shown to act as a potent inducer of cell proliferation, migration or survival in a wide variety of cells not of endothelial origin, including smooth muscle cells, retinal cells and neurons, glial cells, pericytes and mammary tumor cells.[29]–[40] Inhibition of VEGF production in tumor cells may help in treatments for cancer. This evidence concerns the gene VEGFA and breast cancer.