HLA-C and systemic lupus erythematosus: Recent studies have implicated a distinct role for MHC (H-2) class I molecules in mouse lupus pathogenesis: McPhee et al. could demonstrate that β2-microglobulin-deficient (β2m) BXSB-Yaa and -SJL mice (i.e., mice deficient in class I antigen presentation) developed much more aggressive and lethal forms of a lupus-like disease that characterizes these strains [133].