Moreover, c-Abl phosphorylated at T735, a site required for binding 14-3-3 in the cytosol [22], colocalized with amyloid plaques, neurofibrillary tangles (NFTs), and GVD in the entorhinal cortex and hippocampus and brain of AD patients [21, 23]. This evidence concerns the gene ABL1 and Alzheimer disease.