GCG and type 2 diabetes mellitus: These studies suggest a GLP-1-induced inhibition of bone resorption by osteoclasts, through direct effects on osteoblasts both in animal models of type 2 diabetes and metabolic syndrome, thus promoting a further careful evaluation of bone effects in ongoing Phase III clinical trials investigating the efficacy of a long-acting GLP-1 R analog, such as, liraglutide, in the treatment of obesity.