Mixed meal [19] and oral-glucose-load-induced [20] GLP-1 response have been reported to be reduced in Type 2 diabetes in comparison with healthy subjects; considering the possible involvement of GLP-1 in bone metabolism, the impairment of the GLP-1 axis could theoretically contribute to the increased risk of fractures in type 2 diabetes. The gene discussed is GCG; the disease is type 2 diabetes mellitus.