SOD2 and synucleinopathy: This protective effect was observed to take place through overexpression of two FOXO target genes, SOD2 (superoxide dismutase 2, mitochondrial) and Thor. Kuwahara et al. recently [34] studied the role of Serine-129 phosporylation of α-synuclein in the transgenic C. elegans (Tg worm) model of synucleinopathy.