To investigate the influence of Calcr on HSV-1 entry and spread to the CNS in vivo in DA rats, we modulated the calcitonin receptor by injecting rat Amylin, an agonist for calcitonin receptor, or Calcitonin (8–32) (Salmon I), a potent and selective antagonist [16], into the whiskers area prior to the infection. The gene discussed is CALCR; the disease is infection.