Finally, to assess whether the CalcR could serve as a receptor or co-receptor for virus entry in a non-permissive in vitro system, we utilized a rat adeno-carcinoma cell line (CRL-1666) that cannot be readily infected with HSV1 and transfected and infected it in the same way as described above for HEK293T cells. The gene discussed is CALCR; the disease is adenocarcinoma.