PDP1 and Hyperglycemia: Due to the higher activity of the interconvertible enzymes of HGP (GP and FBP2) in the phosphorylated form and the increased activity of the enzymes of HGU (GS, PFK2, PDH, PK) in their dephosphorylated form (Text S5), the hepatic glucose metabolism is shifted from a glucose producing phenotype (HGP) under low glucose concentrations to a glucose consuming phenotype (HGU) at hyperglycemia.