RB1 and Burkitt lymphoma: Several of these paths are already informative upon disease mechanisms (highlighted in Figure 2E,F): i) EBV protein EBNA-LP has been shown to bind to RB1, which in turn regulates MYC, a human gene associated with Burkitt's lymphoma, an EBV-implicated disease [2], [10]; ii) EBV protein EBNA2 binds to host protein RBPJ [2] which regulates Bcl-3[29], which is in turn associated with B cell lymphoma, an EBV-implicated disease [2], [10]; and iii) HPV E6 protein interacts with p53 which regulates TNFRSF10B which is associated with head and neck squamous carcinoma, an HPV16-implicated disease [30].