Serum AFP had a lower diagnostic capability (AUC = 0.60, p > 0.05) of detecting early HCC from late HCC either at a cutoff value of 100 ng/mL (Sen = 64.29%, Spe = 56%) or 400 ng/mL (Sen = 64.29%, Spe = 40%) (Figure 3C), which is in accordance with the acknowledged reports that AFP is insensitive for early HCC detection. This evidence concerns the gene AFP and hepatocellular carcinoma.