To assess the individual performance of hnRNP K as a potential biomarker to discern early HCC from cirrhosis, and to detect early HCC from late HCC in tissue, we selected optimal fixed cutoff thresholds for hnRNP K and then calculated test sensitivity and specificity by receiver operating characteristic (ROC) curves (Figure 3). The gene discussed is HNRNPK; the disease is hepatocellular carcinoma.