Andrew et al (2009) [34] observed gene-environment interaction of 549 controls and 342 cases with arsenic exposure in relation to bladder cancer risk for a variant allele of the double-strand break repair gene XRCC3 T241M (odds ratios (OR) adjusted for age, gender, smoking status (former and current): OR 2.8 (1.1 – 7.3)). This evidence concerns the gene XRCC3 and urinary bladder carcinoma.