TNF and Sepsis: Interestingly cardiomyocytes can generate in large burns and sepsis a multitude of substances such as TNF-α, IL-1β, IL-6, a substance that induces chemotaxis of neutrophils (CINC-1), macrophages migration inhibitory factor (MIF) [65-67], and High Mobility Group Box (HMGB-1), many of which we cite as probable sources of SIMD.