It was found that many substances that act as mediators, which are elevated in sepsis and septic shock, such as tumor necrosis factor (TNF-α) [59-61], interleukin (IL-1β), and a factor called complement anaphylatoxin (C5a), also have cardiodepressant properties in vitro [62, 63]. The gene discussed is IL1B; the disease is Sepsis.