Mehta and coworkers [190], in a single center prospective study with 37 patients with severe sepsis, noted that 16 (43%) had cTnI+ and that these were associated with higher need for inotropic or vasopressor support (p = 0.018), higher APACHE II score (p = 0.004), higher incidence of segmentary Abnormalities of wall motion on echocardiography (p = 0.002) and lower LVEF (p = 0.04). The gene discussed is TNNI3; the disease is Sepsis.