Previously Lappalainen et al. reported that diabetes induced oxidative stress in the rat brain through GSH reduction.[21] Furthermore, Piotrowski et al. depicted that caspase-3 activity, a key enzyme in apoptotic cell death, increased in the hippocampus of diabetic rats.[27] These data showed that diabetes mellitus results in oxidative stress and probably induced apoptosis in the hippocampus. Here, CASP3 is linked to diabetes mellitus.