In support of this, the analysis of epigenetic changes in VSELs identified unique methylation patterns of DMRs in some imprinted genes (Igf2-H19, KCNQ1 and RasGRF1) that, on the one hand, explain the dormant state of VSELs residing in adult tissues (27) but on the other hand, explain the reverse pattern of expression of these genes reported in RMS seen for example in Beckwith-Wiedemann syndrome patients (35–38). This evidence concerns the gene IGF2 and Beckwith-Wiedemann syndrome.