Since the combination of Ras activation along with expression of dominant-negative p53 or SV40 early region proteins and PAX-FOXO1 in murine mesenchymal stem cells (MSCs) leads to formation of ARMS-like tumor cells, we became interested in a potential role of Ras signaling in the pathogenesis of ARMS. This evidence concerns the gene FOXO1 and alveolar rhabdomyosarcoma.