These include fB (fBR32Q, rs641153; protective, OR 0.32) [17], and C3 (C3R102G, rs2230199; risk, OR:2.6) [18]; a recent targeted genotyping approach identified a single nucleotide polymorphism (SNP) just 3′ of the gene encoding fI (CFI) that is associated with reduced AMD risk [19]. This evidence concerns the gene C3 and age-related macular degeneration.