The fHY402H and C3R102G, variants, which are risk factors in AMD/DDD, do not affect aHUS, and the CFHR1/CFHR3 deletion that is protective in AMD, is risk for aHUS, because lack of FHR1 is strongly associated with serum anti-fH autoantibodies [15]. The gene discussed is CFHR3; the disease is age-related macular degeneration.