However, in a recent study, baseline plasma levels of interleukin-8 were correlated with short PFS, while a number of other circulating angiogenic biomarkers, such as basic fibroblast growth factor, placental growth factor, hepatocyte growth factor, stromal-derived factor-1 and macrophage chemoattractant protein-3 were increased before the radiographic development of progressive disease in CRC patients treated with FOLFIRI-Bev [20]. This evidence concerns the gene CXCL8 and colorectal carcinoma.