APP and Alzheimer disease: Importantly, inflammation-induced plaques contained significant amounts of proteolytic APP fragments (Figure 7D,G), as seen in double immune-challenged WT mice (Figure 5H), and were surrounded by Aβ peptides (Figure 7G-I) that had a striking similarity to the morphology of senile Aβ plaques seen in human patients with AD (Figure 7J-L; see Additional file 9: Figure S9).