In this study, the combined results of meta-analysis showed that the 235delC mutant increased the risk of NSHL, but significant between-study heterogeneity and genetic-effect heterogeneity were detected, indicating that the ethnic specificity and regional disparity contributed to the association between the 235delC mutation of GJB2 gene and the NSHL susceptibility. Here, GJB2 is linked to nodular sclerosis classical Hodgkin lymphoma.