The RT-PCR results showed that HMGB1 mRNA level was significantly higher in tumor tissue, compared to that in para-tumor tissue (0.848 ± 0.075 Vs 0.446 ± 0.102, p < 0.001) and that in normal tissue (0.848 ± 0.075 Vs 0.354 ± 0.081, p < 0.001). The gene discussed is HMGB1; the disease is neoplasm.