HMGB1 and neoplasm: Multivariate analysis showed that expression of HMGB1 (p = 0.009, HR = 1.834; 95%CI: 1.167-2.881) and tumor size (p = 0.005, HR = 1.902; 95%CI: 1.209-2.992) were independent prognostic factors for overall survival (Table 2).