Multivariate analysis indicated that expression of HMGB1 (p = 0.018, HR = 1.622; 95%CI: 1.088-2.419) and tumor size (p = 0.012, HR = 1.661; 95%CI: 1.119-2.465) were independent prognostic factors for disease-free survival (Table 2). The gene discussed is HMGB1; the disease is neoplasm.