The Western blot analysis of HMGB1 protein also showed that the expression of HMGB1 protein was significantly higher in tumor tissue, compared to that in para-tumor tissue (0.781 ± 0.105 Vs 0.230 ± 0.070, p < 0.001) and that in normal tissue (0.781 ± 0.105 Vs 0.180 ± 0.062, p < 0.001, Figure 1). Here, HMGB1 is linked to neoplasm.