Analysis of the murine model of CMT4C revealed that the capacity of SH3TC2-deficient Schwann cells to properly myelinate underlying axons is affected at the early stages of myelination, which is in line with the early onset of the neuropathy reported in CMT4C patients [69–71]. The gene discussed is SH3TC2; the disease is Charcot-Marie-Tooth disease type 4C.