Given that MOAP-1 regulates RASSF1A pro-apoptotic function and RASSF1A is also epigenetically silenced in a large number of human cancers, it is possible that the combined loss of MOAP-1 and RASSF1A during carcinogenesis may result in the inhibition of extrinsically activated cell death signaling pathways in cancer cells. This evidence concerns the gene RASSF1 and cancer.