The presence of increased intracavernosal pressure associated with the amplified corpus cavernosum relaxation response (priapism) mediated by NO-cGMP signaling pathway, the lack of RhoA/ROCK-mediated vasoconstriction in sickle cell transgenic Berkeley mice, and the association of priapism with genitourinary infections and urinary retention further suggest the possibility that changes in the DSM reactivity may contribute to urogenital complications in SCD [36, 38–40, 192]. This evidence concerns the gene RHOA and Priapism.