PLA VEGFR-3/PI3K signals were also detected in cancer cells surrounding the lymphatic vessels in the metastatic samples (Figure 6A, top and bottom panels), whereas in non-metastatic samples they were detected mostly in cells distant to the lymphatic vessels (Fig, 6B, right bottom panel), but rarely in those containing within or surrounding the non-metastatic lymphatic vessels (Figure 6B, top right panel). This evidence concerns the gene FLT4 and cancer.