The analysis of how molecule levels change during the progression to more advanced stages, showed that IL-1α, IL-2R, IL-12, IL-18, CXCL9, MIF and HGF are higher in CHD, LC and LCD than in patients with only type 2 diabetes or CHC suggesting that these proteins are associative markers of these two diseases and implicated in their complicance and progression. This evidence concerns the gene MIF and lattice corneal dystrophy type I.