The analysis of how molecule levels change during the progression to more advanced stages, showed that IL-1α, IL-2R, IL-12, IL-18, CXCL9, MIF and HGF are higher in CHD, LC and LCD than in patients with only type 2 diabetes or CHC suggesting that these proteins are associative markers of these two diseases and implicated in their complicance and progression. Here, IL18 is linked to cryohydrocytosis.