Insulin, PAI-1, adiponectin, resistin and adipsin levels are similar in both groups whereas GIP is lower in LCs than in CHC patients (with p-value <0.05) and C-peptide, IL-1α, IL-2R, IL-12, IL-18, CXCL9, MIF, β-NGF, HGF and leptin are higher in LCs than in CHC patients (with p-value <0.05). The gene discussed is SERPINE1; the disease is cryohydrocytosis.