INS and neoplasm: In fact, β-NGF is involved in cancer growth and metastasis and it has also been detected in diseased liver tissues [11], CXCL1 and CXCL9 have chemotactic activities and roles in angiogenesis, inflammation and tumor genesis [10], adiponectin is expressed on monocytes and macrophages that mediate the stimulation of protein kinase activated by AMP, the oxidation of fatty acids and the uptake of glucose [42], whereas C-peptide is implicated in insulin resistance [5] and GIP induces insulin secretion [27].