The side by side comparison between WT mice primary neurons and AD Tg mice primary neurons showed that there were higher baseline levels of Tau-PS262 in AD Tg mice primary neurons than in WT mice primary neurons: lanes 1 to 3 versus lanes 7 to 9 (Figure 3e), 100% versus 1,207%, **P = 0.0014 (Figure 3f). Here, MAPT is linked to Alzheimer disease.