MAPT and Alzheimer disease: These studies would promote more research to investigate the effects of anesthesia on tau phosphorylation and other AD neuropathogenesis, which may include assessing the effects of different anesthetics (e.g., isoflurane versus desflurane) on the levels of phosphorylated tau at different epitopes, total tau, tau-associated kinases and phosphatases in both WT and AD Tg mice, as well as the functional relevance (e.g., learning and memory impairment).