Similarly, the isoflurane anesthesia led to increases in the levels of Tau-PS262 in the AD Tg mice brain tissues at 12 hours: 100% versus 377%, **P = 0.0016 (Figure 2c and Figure 2d); and 24 hours after the anesthesia: 100% versus 401%, *P = 0.044 (Figure 2e and Figure 2f). Here, MAPT is linked to Alzheimer disease.