MAPT and Alzheimer disease: There are higher Aβ levels in the AD Tg mice [B6.Cg-Tg(APPswe, PSEN1dE9) 85Dbo/J mice] brain tissues than in WT mice brain tissues [35], therefore these results suggest that Aβ may potentiate the isoflurane-induced increase in phosphorylated tau levels.