HFE and hyperinsulinemic hypoglycemia, familial, 4: Despite pulmonary hepcidin deficiency and reduced iron levels in macrophages of untreated Hfe−/− mice, we observed similar levels of intracellular iron accumulation in AM of wild-type, Hfe−/−, HfeLysMCre (−) and HfeLysMCre (+) mice in response to LPS treatment.