Moreover, as predicted by previous studies of transgenic mice expressing a constitutively active Akt construct specifically in skeletal muscle [8], the ursolic acid-mediated increase in skeletal muscle Akt activity was associated with skeletal muscle hypertrophy, increased energy expenditure, and reduced total body weight, white fat, glucose intolerance and hepatic steatosis. This evidence concerns the gene AKT1 and Glucose intolerance.