On the effects of Th17 cells on CHB pathogenesis, we supposed they might be a progressive factor of HBV-LF since we observed a significantly correlation of Th17 frequency with liver injury and fibrosis degree, no significant correlation between Th17 frequency and HBV load, and moreover, IL-17 cytokines mainly produced by Th17 cells could dramatically promote the activation and proliferation of HSCs, the cornerstone of liver fibrosis. Here, IL17A is linked to Hepatic fibrosis.