PENK and cannabis dependence: Relative to the reference group, those with high Neuroticism (OR = 1.3, p = .85) or an at-risk SNP (PENK rs2609997; OR = 1.8, p = .26) did not have notable increased risk, but those with high Neuroticism and the at-risk SNP had an over 9-fold increased clinical diagnosis of cannabis dependence (OR = 9.2, p = .0007).