PENK and cannabis dependence: Relative to the reference group, those with both at-risk SNP (PENK rs2576773) and high Neuroticism had an over 8-fold increased clinical diagnosis of cannabis dependence (OR = 8.35, p = .001), compared to those with only Neuroticism (OR = 0.93, p = .99) or the at-risk SNP (OR = 2.41, p = .27).