A second study on a mouse model of dietary-induced sporadic colon cancer showed that the very first measurable change before tumor onset consists of ectopic expression of Paneth cell markers together with transcriptional activation of Fzd5 and EphB2, two members of the Wnt signaling cascade necessary for Paneth cell differentiation and localization [51]. The gene discussed is FZD5; the disease is malignant colon neoplasm.