Elevated expression of cytokines like IL-3 and Kit ligand are a part of the pathogenesis of diseases such as Chronic Myeloid Leukaemia, the proven ability of increased HMGA1 expression to bind the Kit ligand promoter and enhance expression thereof adds another facet to the pleiotropic effects of elevated HMGA1 expression [32]. The gene discussed is HMGA1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.