NPM1 and anaplastic large cell lymphoma: They can result from point mutations, reciprocal chromosomal translocations and internal tandem duplication; thus in Anaplastic Large Cell Lymphoma (ALCL) the t(2∶5) translocation leads to the formation of the NPM/ALK gene which encodes a lymphoma specific NPM/ALK protein with intrinsic and disregulated PTK activity [1].