There was no clustering of the oncogenes involved in the myeloproliferative disorders and whilst FLT3ITD, KIT D816V, Fip1L/PDGFRα (all type 3 leukaemogenic receptor PTKs), did show a greater, though very limited, similarity compared with other oncogenes, TEL/PDGFRβ, another type 3 receptor PTK did not cluster with these structurally similar kinases in respect of proteomic effects. The gene discussed is PTK2B; the disease is myeloproliferative disorder.