As shown in Fig. 6A, C, D, F, the activity of caspase-3 and caspase-9 is increased in a dose-and time-dependent manner compared with untreated cells in three cancer cells; the activity of caspase-8 linked to the death receptors fails to be increased in CFPAC-1 and BxPC-3 cells (Fig. 6B, E). Here, CASP8 is linked to cancer.