ITGAM and neoplasm: Finally, we appreciated similar trends with regard to the percentage of macrophages (CD11b + F4/80+) of total splenic leukocytes: we observed an increase from 2.2% in tumor naïve mice to 5.4% in mice bearing large tumors (p = 0.02); following surgical resection the percentage of macrophages decreased to 2.3% (p = 0.02) (Figure 5A-bottom panel).