In general, the distribution of HD-relevant genes seems to reflect the widespread subcellular location of the different products of Htt gene products: wild-type Htt is primarily a cytoplasmic protein associated with a variety of cellular structures and organelles such as microtubules, vesicles, Golgi complex, endoplasmic reticulum and axon terminals of neurons; whereas fragments of mutant Htt can also be found in inclusion bodies in the nucleus [56-58]. The gene discussed is HTT; the disease is Huntington disease.