Two small studies examining mRNA transcript levels in placentas of IUGR and normal birthweight infants reported differential expression of some placentally imprinted genes (Diplas et al. 2009; McMinn et al. 2006); a third reported lower IGF2 and loss of IGF2 imprints (Koukoura et al. 2011a) as well as higher H19 transcript levels and increased H19 expression (Koukoura et al. 2011b) in growth-restricted placentas. This evidence concerns the gene IGF2 and fetal growth restriction.