Other significantly different biological parameters between IgAN and non-IgAN, such as TP, ALB, CH, TG, LDL and sIgG, were also linked to the different proportion of nephrotic syndrome (Table 2), which is characterized by mass proteinuria, hypoalbuminemia, edema, and varying degrees of hyperlipidemia [36]. The gene discussed is ALB; the disease is Hypoalbuminemia.