Uniquely unmethylated genes in PTSD cases were associated immune system involvement, including toll-like receptor 1 (TLR1), toll-like receptor 3 (TLR3) (innate immune system), interleukin 8 (IL8), lymphotoxin alpha (LTA), and killer cell lectin-like receptor G1 (KLRG-1) (adaptive immune system) [30]. This evidence concerns the gene TLR1 and post-traumatic stress disorder.