For example, Heesen et al. found similar resting serum concentrations of IFN- γ, TNF- α and IL-10 in trained and untrained MS patients [62], whereas White et al. reported reduced resting plasma concentrations of IL-4, IL-10, C-reactive protein (CRP) and IFN- γ and a tendency for decreased TNF- α in MS patients upon eight weeks of PRE. This evidence concerns the gene CRP and myeloid sarcoma.