INS and diabetes mellitus: Findings from animal studies and metabolic studies in human suggests that adiponectin has different properties, such as suppression of hepatic gluconeogenesis, stimulation of fatty acid oxidation in the liver, glucose uptake in skeletal muscle and stimulation of insulin secretion.[8][9] According to most of the studies in different populations, higher adiponectin level is associated with a lower risk of diabetes[10] and low plasma level of adiponectin is associated with increased insulin resistance both in children and adults.[11]