A treatment with metformin for six months lowers CRP serum level in all subjects as well as obese and non–obese.[12] Another acute phase reactants of inflammation is ferritin which is higher than nor-mal in patients with metabolic syndrome, T2DM pa-tients and PCOS.[13][14][15] Serum ferritin levels in over-weight and obese women with PCOS are significantly higher compared to overweight and obese women without this disorder.[15][16][17][18]. This evidence concerns the gene CRP and polycystic ovary syndrome.