APOE and Alzheimer disease: Different OR for ε4 allele in men and women indicates that risk of AD in male APOE-ε4 allele carriers (OR=8.421, CI=1.894-37.44) is higher than female carriers (OR=5.846, CI=2.173-15.73), so it seems that despite the agedependant and dosage-dependent manner of this allele which were investigated in Iranian population by Raygani et al.,[22] it may act in a sex-dependent way as well.