As hundreds genes have been known as the risk factors for late onset AD, the well-known one is apolipoprotein E gene (APOE) which has been recognized as the most important risk factor in 65% of sporadic cases.[3] Apolipoprotein E is the main part of very low density lipoproteins, intermediate density lipoproteins (IDL), chylomicrons and the main cholesterol carrier in the brain and its synthesis is independent in central nervous system (CNS) and lung. This evidence concerns the gene APOE and Alzheimer disease.