DNMT1 and cancer: Additionally, zebularine has also antiproliferative activity that will be more effective in cancer cells than in normal cells.[109][110][111][112][113][114][115] The oligodeoxynucleotide MG98, is another MTase inhibitor which binds with the 3’-UTR region of the DNMT1 mRNA and leads to its degradation before translation.[116] One disadvantage of the MTase inhibitor is that the chromosomal site of demethylation cannot be controlled.