The functional significance of an AR mutation in PCa is represented in the LNCaP cell line where the AR gene is mutated at codon 877 (Thr to Ala).[12] Due to this mutation, the growth of LNCaP is stimulated in vitro not only by androgens, but also by non-androgenic steroids (e.g., estrogens, progesterone) and anti-androgens. The gene discussed is AR; the disease is posterior cortical atrophy.