TP53 and posterior cortical atrophy: Kibel et al investigated nine SNPs of TP53, CCND1, CDKN1A, CDKN1B, CDKN2A, and MDM2 and discovered that the t allele of MDM2 was the most promising allele associated with PCa.[39] The presence of at least one copy of the t allele of MDM2 tSNP309g was associated with an increased risk of advanced PCa (odds ratio [OR] 2.26, 95% CI 1.15–4.46).