VDR and posterior cortical atrophy: The association between Vitamin D and PCa risk remains controversial.[55][56][57] The anti-proliferative effects of activated Vitamin D are thought to be mediated through a pathway that involves Vitamin D Receptors (VDRs).[58] It is possible that VDR gene polymorphisms could affect the binding of biologically active vitamin D and modulate the anti-proliferative effects of Vitamin D. Several studies focused on the six polymorphic loci (Cdx2, FokI, BsmI, ApaI, TaqI, and the poly A microsatellite) of the most common VDR variants.