Bastian et al., in a study using matched tumor and normal tissues of 53 patients, discovered that the combined hypermethylation of GSTpi, APC, and PTGS2 gene correlated with other clinical or pathological variables (e., pT-stage, Gleason score), with 71.1% to 96.2% sensitivity and 92.9% to 100% specificity.[103] APC and PSTG2 methylation status appear to have a higher prognostic value of PCa in several studies completed to date. The gene discussed is APC; the disease is posterior cortical atrophy.