AR and posterior cortical atrophy: Somatic AR mutation (599 S>G) in this cell line was proved to be as dominant-negative or loss-of-function type.[23] In addition, in author’s laboratory, a germline AR (A1675T:T559S) substitution mutation in the DNA-binding domain was discovered for the first time in three PCa-affected members of an African-American family with a history of early-onset disease.[24]